rs2066844
Variant in the NOD2 gene (Nucleotide Binding Oligomerization Domain Containing 2)
rs2066844 is a single nucleotide polymorphism (SNP) in the NOD2 gene, involved in intracellular bacterial sensing / autophagy. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2066844 variant?
rs2066844 is a SNP (single nucleotide polymorphism) in the NOD2 (Nucleotide Binding Oligomerization Domain Containing 2) gene. It belongs to the Immune Signaling category and is part of the Viral Defense & Interferon Response biological cluster. NOD2 encodes an intracellular sensor for bacterial muramyl dipeptide that activates NF-kB and autophagy; mutations cause Crohn's disease.
Biological role and pathway
This variant sits within the NOD2 gene, which is involved in the intracellular bacterial sensing / autophagy pathway. Genes within the Viral Defense & Interferon Response cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2066844 and Long COVID / ME-CFS research
NOD2 senses intracellular bacterial components from gut dysbiosis; variants causing reduced NOD2 function may impair gut innate immune defense and autophagy, contributing to gut microbiome dysbiosis in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: NOD2
rs2066844 is one of 3 known variants in the NOD2 gene. To understand the full biological context of this variant, explore the parent gene page.
View NOD2 gene page →Conditions studied in relation to rs2066844
Research into NOD2 variants including rs2066844 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include NOD2 and the rs2066844 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the NOD2 gene
The following variants in NOD2 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2066844 variant in the NOD2 gene?
rs2066844 is a single nucleotide polymorphism (SNP) located in the NOD2 (Nucleotide Binding Oligomerization Domain Containing 2) gene, which is involved in intracellular bacterial sensing / autophagy. NOD2 encodes an intracellular sensor for bacterial muramyl dipeptide that activates NF-kB and autophagy; mutations cause Crohn's disease.
How may the rs2066844 variant relate to Long COVID or ME/CFS?
NOD2 senses intracellular bacterial components from gut dysbiosis; variants causing reduced NOD2 function may impair gut innate immune defense and autophagy, contributing to gut microbiome dysbiosis in Long COVID.
Can a consumer DNA test detect the rs2066844 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2066844 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for NOD2 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33153018
- [2]Nature Genetics
- [3]NEJM