rs2880058
Variant in the NOS1AP gene (Nitric Oxide Synthase 1 Adaptor Protein)
rs2880058 is a single nucleotide polymorphism (SNP) in the NOS1AP gene, involved in neuronal NOS / cardiac repolarization. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2880058 variant?
rs2880058 is a SNP (single nucleotide polymorphism) in the NOS1AP (Nitric Oxide Synthase 1 Adaptor Protein) gene. It belongs to the Cardiovascular category and is part of the Autonomic Nervous System biological cluster. NOS1AP encodes a scaffolding protein that interacts with nNOS and regulates cardiac QT interval.
Biological role and pathway
This variant sits within the NOS1AP gene, which is involved in the neuronal NOS / cardiac repolarization pathway. Genes within the Autonomic Nervous System cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2880058 and Long COVID / ME-CFS research
NOS1AP variants are the strongest common genetic determinants of QT interval variation; prolonged QT and cardiac arrhythmias are documented in Long COVID and POTS, making NOS1AP variants potentially relevant.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: NOS1AP
rs2880058 is one of 2 known variants in the NOS1AP gene. To understand the full biological context of this variant, explore the parent gene page.
View NOS1AP gene page →Conditions studied in relation to rs2880058
Research into NOS1AP variants including rs2880058 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include NOS1AP and the rs2880058 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the NOS1AP gene
The following variants in NOS1AP are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2880058 variant in the NOS1AP gene?
rs2880058 is a single nucleotide polymorphism (SNP) located in the NOS1AP (Nitric Oxide Synthase 1 Adaptor Protein) gene, which is involved in neuronal NOS / cardiac repolarization. NOS1AP encodes a scaffolding protein that interacts with nNOS and regulates cardiac QT interval.
How may the rs2880058 variant relate to Long COVID or ME/CFS?
NOS1AP variants are the strongest common genetic determinants of QT interval variation; prolonged QT and cardiac arrhythmias are documented in Long COVID and POTS, making NOS1AP variants potentially relevant.
Can a consumer DNA test detect the rs2880058 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2880058 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for NOS1AP and its variants. This is not an exhaustive literature review.
- [1]PMID: 32966261
- [2]Nature Genetics
- [3]Circulation