rs2297518

What is the rs2297518 variant?

rs2297518 is a SNP (single nucleotide polymorphism) in the NOS2 (Nitric Oxide Synthase 2 (Inducible)) gene. It belongs to the Immune Signaling category and is part of the Innate Immunity & Pattern Recognition biological cluster. NOS2 encodes inducible NOS (iNOS), which produces high levels of nitric oxide in macrophages and other immune cells as an antimicrobial agent.

Biological role and pathway

This variant sits within the NOS2 gene, which is involved in the nitric oxide-mediated immunity pathway. Genes within the Innate Immunity & Pattern Recognition cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: NOS2

rs2297518 is one of 2 known variants in the NOS2 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs2297518

Research into NOS2 variants including rs2297518 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include NOS2 and the rs2297518 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the NOS2 gene

The following variants in NOS2 are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions