rs146410978
Variant in the NOTCH1 gene (Notch Receptor 1)
rs146410978 is a single nucleotide polymorphism (SNP) in the NOTCH1 gene, involved in Notch signaling / immune cell differentiation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs146410978 variant?
rs146410978 is a SNP (single nucleotide polymorphism) in the NOTCH1 (Notch Receptor 1) gene. It belongs to the Signaling category and is part of the Immune System & Inflammation biological cluster. NOTCH1 encodes the primary Notch receptor mediating cell-fate decisions in development and immune cell differentiation.
Biological role and pathway
This variant sits within the NOTCH1 gene, which is involved in the Notch signaling / immune cell differentiation pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs146410978 and Long COVID / ME-CFS research
Notch signaling directs T cell and innate lymphoid cell differentiation; variants may affect immune cell fate decisions during COVID-19 infection with implications for Long COVID immune dysregulation.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: NOTCH1
rs146410978 is one of 1 known variant in the NOTCH1 gene. To understand the full biological context of this variant, explore the parent gene page.
View NOTCH1 gene page →Conditions studied in relation to rs146410978
Research into NOTCH1 variants including rs146410978 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include NOTCH1 and the rs146410978 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the NOTCH1 gene
The following variants in NOTCH1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs146410978 variant in the NOTCH1 gene?
rs146410978 is a single nucleotide polymorphism (SNP) located in the NOTCH1 (Notch Receptor 1) gene, which is involved in Notch signaling / immune cell differentiation. NOTCH1 encodes the primary Notch receptor mediating cell-fate decisions in development and immune cell differentiation.
How may the rs146410978 variant relate to Long COVID or ME/CFS?
Notch signaling directs T cell and innate lymphoid cell differentiation; variants may affect immune cell fate decisions during COVID-19 infection with implications for Long COVID immune dysregulation.
Can a consumer DNA test detect the rs146410978 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs146410978 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for NOTCH1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32296168
- [2]Nature Genetics
- [3]Cell