rs16139
Variant in the NPY gene (Neuropeptide Y)
rs16139 is a single nucleotide polymorphism (SNP) in the NPY gene, involved in sympathetic nervous system signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs16139 variant?
rs16139 is a SNP (single nucleotide polymorphism) in the NPY (Neuropeptide Y) gene. It belongs to the Autonomic category and is part of the Autonomic Nervous System biological cluster. NPY encodes neuropeptide Y, a major sympathetic neurotransmitter that regulates energy balance, vasoconstriction, and anxiety.
Biological role and pathway
This variant sits within the NPY gene, which is involved in the sympathetic nervous system signaling pathway. Genes within the Autonomic Nervous System cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs16139 and Long COVID / ME-CFS research
NPY signaling modulates autonomic tone, stress responses, and immune function, potentially contributing to POTS and anxiety in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: NPY
rs16139 is one of 2 known variants in the NPY gene. To understand the full biological context of this variant, explore the parent gene page.
View NPY gene page →Conditions studied in relation to rs16139
Research into NPY variants including rs16139 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include NPY and the rs16139 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the NPY gene
The following variants in NPY are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs16139 variant in the NPY gene?
rs16139 is a single nucleotide polymorphism (SNP) located in the NPY (Neuropeptide Y) gene, which is involved in sympathetic nervous system signaling. NPY encodes neuropeptide Y, a major sympathetic neurotransmitter that regulates energy balance, vasoconstriction, and anxiety.
How may the rs16139 variant relate to Long COVID or ME/CFS?
NPY signaling modulates autonomic tone, stress responses, and immune function, potentially contributing to POTS and anxiety in Long COVID.
Can a consumer DNA test detect the rs16139 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs16139 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for NPY and its variants. This is not an exhaustive literature review.
- [1]PMID: 33948838
- [2]Nature Genetics
- [3]Journal of Clinical Investigation