rs4795424

What is the rs4795424 variant?

rs4795424 is a SNP (single nucleotide polymorphism) in the NR1D1 (Nuclear Receptor Subfamily 1 Group D Member 1) gene. It belongs to the Circadian Rhythm category and is part of the Neurological & Sleep biological cluster. NR1D1 (REV-ERBα) is a nuclear receptor and transcriptional repressor that forms the secondary feedback loop of the circadian clock, regulating BMAL1 expression and linking circadian timing to metabolism and immunity.

Biological role and pathway

This variant sits within the NR1D1 gene, which is involved in the circadian clock pathway. Genes within the Neurological & Sleep cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: NR1D1

rs4795424 is one of 3 known variants in the NR1D1 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs4795424

Research into NR1D1 variants including rs4795424 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include NR1D1 and the rs4795424 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the NR1D1 gene

The following variants in NR1D1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions