rs2285933
Variant in the OAS1 gene (2'-5'-Oligoadenylate Synthetase 1)
rs2285933 is a single nucleotide polymorphism (SNP) in the OAS1 gene, involved in innate antiviral defense / RNase L activation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2285933 variant?
rs2285933 is a SNP (single nucleotide polymorphism) in the OAS1 (2'-5'-Oligoadenylate Synthetase 1) gene. It belongs to the Antiviral category and is part of the Viral Defense & Interferon Response biological cluster. OAS1 encodes an antiviral enzyme that synthesizes 2-5A oligoadenylates upon dsRNA recognition, activating RNase L to degrade viral RNA.
Biological role and pathway
This variant sits within the OAS1 gene, which is involved in the innate antiviral defense / RNase L activation pathway. Genes within the Viral Defense & Interferon Response cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2285933 and Long COVID / ME-CFS research
OAS1 splice variants and the p46 isoform (prenylated form) are strongly associated with COVID-19 severity; variants affect antiviral defense that may influence viral persistence in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: OAS1
rs2285933 is one of 2 known variants in the OAS1 gene. To understand the full biological context of this variant, explore the parent gene page.
View OAS1 gene page →Conditions studied in relation to rs2285933
Research into OAS1 variants including rs2285933 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include OAS1 and the rs2285933 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the OAS1 gene
The following variants in OAS1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2285933 variant in the OAS1 gene?
rs2285933 is a single nucleotide polymorphism (SNP) located in the OAS1 (2'-5'-Oligoadenylate Synthetase 1) gene, which is involved in innate antiviral defense / RNase L activation. OAS1 encodes an antiviral enzyme that synthesizes 2-5A oligoadenylates upon dsRNA recognition, activating RNase L to degrade viral RNA.
How may the rs2285933 variant relate to Long COVID or ME/CFS?
OAS1 splice variants and the p46 isoform (prenylated form) are strongly associated with COVID-19 severity; variants affect antiviral defense that may influence viral persistence in Long COVID.
Can a consumer DNA test detect the rs2285933 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2285933 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for OAS1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 34385711
- [2]Science
- [3]Nature Genetics