rs2072136

What is the rs2072136 variant?

rs2072136 is a SNP (single nucleotide polymorphism) in the OAS3 (2'-5'-Oligoadenylate Synthetase 3) gene. It belongs to the Antiviral category and is part of the Viral Defense & Interferon Response biological cluster. OAS3 encodes the large OAS isoform with the highest antiviral activity in the OAS family.

Biological role and pathway

This variant sits within the OAS3 gene, which is involved in the innate antiviral defense pathway. Genes within the Viral Defense & Interferon Response cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: OAS3

rs2072136 is one of 1 known variant in the OAS3 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs2072136

Research into OAS3 variants including rs2072136 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include OAS3 and the rs2072136 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the OAS3 gene

The following variants in OAS3 are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions