rs2285884
Variant in the OASL gene (2'-5'-Oligoadenylate Synthetase Like)
rs2285884 is a single nucleotide polymorphism (SNP) in the OASL gene, involved in antiviral response. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2285884 variant?
rs2285884 is a SNP (single nucleotide polymorphism) in the OASL (2'-5'-Oligoadenylate Synthetase Like) gene. It belongs to the Innate Immunity category and is part of the Innate Immunity & Interferons biological cluster. OASL is an interferon-stimulated gene and pseudoenzyme that lacks OAS catalytic activity but potentiates RIG-I signaling. It enhances antiviral innate immunity against RNA viruses.
Biological role and pathway
This variant sits within the OASL gene, which is involved in the antiviral response pathway. Genes within the Innate Immunity & Interferons cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2285884 and Long COVID / ME-CFS research
OASL expression is elevated in severe COVID-19 as part of the interferon response. As a component of the antiviral ISG landscape, OASL variants may influence the magnitude of interferon-stimulated antiviral defenses relevant to SARS-CoV-2 control and Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: OASL
rs2285884 is one of 2 known variants in the OASL gene. To understand the full biological context of this variant, explore the parent gene page.
View OASL gene page →Conditions studied in relation to rs2285884
Research into OASL variants including rs2285884 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include OASL and the rs2285884 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the OASL gene
The following variants in OASL are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2285884 variant in the OASL gene?
rs2285884 is a single nucleotide polymorphism (SNP) located in the OASL (2'-5'-Oligoadenylate Synthetase Like) gene, which is involved in antiviral response. OASL is an interferon-stimulated gene and pseudoenzyme that lacks OAS catalytic activity but potentiates RIG-I signaling. It enhances antiviral innate immunity against RNA viruses.
How may the rs2285884 variant relate to Long COVID or ME/CFS?
OASL expression is elevated in severe COVID-19 as part of the interferon response. As a component of the antiviral ISG landscape, OASL variants may influence the magnitude of interferon-stimulated antiviral defenses relevant to SARS-CoV-2 control and Long COVID.
Can a consumer DNA test detect the rs2285884 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2285884 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for OASL and its variants. This is not an exhaustive literature review.
- [1]PMID: 25092902
- [2]Nature Immunology
- [3]PNAS