rs1516862
Variant in the P2RX3 gene (Purinergic Receptor P2X 3)
rs1516862 is a single nucleotide polymorphism (SNP) in the P2RX3 gene, involved in ATP-gated ion channel / nociception. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1516862 variant?
rs1516862 is a SNP (single nucleotide polymorphism) in the P2RX3 (Purinergic Receptor P2X 3) gene. It belongs to the Neurological category and is part of the Neurological & Cognitive Function biological cluster. P2RX3 encodes the P2X3 ATP-gated ion channel on sensory neurons, mediating chronic cough, pain, and autonomic reflexes.
Biological role and pathway
This variant sits within the P2RX3 gene, which is involved in the ATP-gated ion channel / nociception pathway. Genes within the Neurological & Cognitive Function cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1516862 and Long COVID / ME-CFS research
P2RX3 on sensory neurons mediates pain and autonomic reflexes; variants may affect pain threshold and the chronic cough reported in some Long COVID patients.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: P2RX3
rs1516862 is one of 1 known variant in the P2RX3 gene. To understand the full biological context of this variant, explore the parent gene page.
View P2RX3 gene page →Conditions studied in relation to rs1516862
Research into P2RX3 variants including rs1516862 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include P2RX3 and the rs1516862 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the P2RX3 gene
The following variants in P2RX3 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1516862 variant in the P2RX3 gene?
rs1516862 is a single nucleotide polymorphism (SNP) located in the P2RX3 (Purinergic Receptor P2X 3) gene, which is involved in ATP-gated ion channel / nociception. P2RX3 encodes the P2X3 ATP-gated ion channel on sensory neurons, mediating chronic cough, pain, and autonomic reflexes.
How may the rs1516862 variant relate to Long COVID or ME/CFS?
P2RX3 on sensory neurons mediates pain and autonomic reflexes; variants may affect pain threshold and the chronic cough reported in some Long COVID patients.
Can a consumer DNA test detect the rs1516862 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1516862 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for P2RX3 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33664986
- [2]Nature Genetics
- [3]Nature