rs1799768
Variant in the SERPINE1 gene (Serpin Family E Member 1 (PAI-1))
rs1799768 is a single nucleotide polymorphism (SNP) in the SERPINE1 gene, involved in fibrinolysis inhibition. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1799768 variant?
rs1799768 is a SNP (single nucleotide polymorphism) in the SERPINE1 (Serpin Family E Member 1 (PAI-1)) gene. It belongs to the Coagulation category and is part of the Coagulation & Microcirculation biological cluster. SERPINE1 encodes PAI-1, the primary inhibitor of tissue plasminogen activator (tPA) and urokinase plasminogen activator, preventing fibrinolysis.
Biological role and pathway
This variant sits within the SERPINE1 gene, which is involved in the fibrinolysis inhibition pathway. Genes within the Coagulation & Microcirculation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1799768 and Long COVID / ME-CFS research
PAI-1 is markedly elevated in COVID-19, suppressing fibrinolysis and promoting microthrombus formation; 4G/5G promoter variants affecting PAI-1 levels may influence Long COVID coagulopathy severity.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: SERPINE1
rs1799768 is one of 2 known variants in the SERPINE1 gene. To understand the full biological context of this variant, explore the parent gene page.
View SERPINE1 gene page →Conditions studied in relation to rs1799768
Research into SERPINE1 variants including rs1799768 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SERPINE1 and the rs1799768 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the SERPINE1 gene
The following variants in SERPINE1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1799768 variant in the SERPINE1 gene?
rs1799768 is a single nucleotide polymorphism (SNP) located in the SERPINE1 (Serpin Family E Member 1 (PAI-1)) gene, which is involved in fibrinolysis inhibition. SERPINE1 encodes PAI-1, the primary inhibitor of tissue plasminogen activator (tPA) and urokinase plasminogen activator, preventing fibrinolysis.
How may the rs1799768 variant relate to Long COVID or ME/CFS?
PAI-1 is markedly elevated in COVID-19, suppressing fibrinolysis and promoting microthrombus formation; 4G/5G promoter variants affecting PAI-1 levels may influence Long COVID coagulopathy severity.
Can a consumer DNA test detect the rs1799768 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1799768 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for SERPINE1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32966261
- [2]Nature Genetics
- [3]NEJM