rs13214716

What is the rs13214716 variant?

rs13214716 is a SNP (single nucleotide polymorphism) in the PANX1 (Pannexin 1) gene. It belongs to the Neurological category and is part of the Neurological & Cognitive Function biological cluster. PANX1 encodes pannexin-1, a membrane channel that releases ATP as a danger signal and contributes to inflammasome activation.

Biological role and pathway

This variant sits within the PANX1 gene, which is involved in the ATP release / inflammasome / gap junction pathway. Genes within the Neurological & Cognitive Function cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: PANX1

rs13214716 is one of 1 known variant in the PANX1 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs13214716

Research into PANX1 variants including rs13214716 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include PANX1 and the rs13214716 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions