rs10945614

What is the rs10945614 variant?

rs10945614 is a SNP (single nucleotide polymorphism) in the PRKN (Parkin RBR E3 Ubiquitin Protein Ligase (Parkin)) gene. It belongs to the Mitophagy category and is part of the Mitochondrial Energy Production & PEM biological cluster. PRKN encodes Parkin, an E3 ubiquitin ligase recruited to depolarized mitochondria by PINK1 to ubiquitinate outer mitochondrial membrane proteins and initiate mitophagy.

Biological role and pathway

This variant sits within the PRKN gene, which is involved in the mitophagy / ubiquitin-proteasome system pathway. Genes within the Mitochondrial Energy Production & PEM cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: PRKN

rs10945614 is one of 2 known variants in the PRKN gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs10945614

Research into PRKN variants including rs10945614 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include PRKN and the rs10945614 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the PRKN gene

The following variants in PRKN are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions