rs3219090
Variant in the PARP1 gene (Poly(ADP-Ribose) Polymerase 1)
rs3219090 is a single nucleotide polymorphism (SNP) in the PARP1 gene, involved in DNA damage response. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs3219090 variant?
rs3219090 is a SNP (single nucleotide polymorphism) in the PARP1 (Poly(ADP-Ribose) Polymerase 1) gene. It belongs to the Dna Repair category and is part of the DNA Repair & Genomic Stability biological cluster. PARP1 detects DNA strand breaks and synthesizes poly(ADP-ribose) chains to recruit repair factors. It consumes large amounts of NAD+ during DNA damage responses and is a major regulator of cell death decisions.
Biological role and pathway
This variant sits within the PARP1 gene, which is involved in the DNA damage response pathway. Genes within the DNA Repair & Genomic Stability cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs3219090 and Long COVID / ME-CFS research
PARP1 activation during viral infection can deplete cellular NAD+ stores. PARP1 variants may affect the balance between DNA repair and NAD+ availability, influencing both viral clearance efficiency and post-infectious energy depletion.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: PARP1
rs3219090 is one of 3 known variants in the PARP1 gene. To understand the full biological context of this variant, explore the parent gene page.
View PARP1 gene page →Conditions studied in relation to rs3219090
Research into PARP1 variants including rs3219090 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include PARP1 and the rs3219090 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the PARP1 gene
The following variants in PARP1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs3219090 variant in the PARP1 gene?
rs3219090 is a single nucleotide polymorphism (SNP) located in the PARP1 (Poly(ADP-Ribose) Polymerase 1) gene, which is involved in DNA damage response. PARP1 detects DNA strand breaks and synthesizes poly(ADP-ribose) chains to recruit repair factors. It consumes large amounts of NAD+ during DNA damage responses and is a major regulator of cell death decisions.
How may the rs3219090 variant relate to Long COVID or ME/CFS?
PARP1 activation during viral infection can deplete cellular NAD+ stores. PARP1 variants may affect the balance between DNA repair and NAD+ availability, influencing both viral clearance efficiency and post-infectious energy depletion.
Can a consumer DNA test detect the rs3219090 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs3219090 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for PARP1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 28094490
- [2]Nature Reviews Molecular Cell Biology
- [3]DNA Repair