rs1801186
Variant in the PCCA gene (Propionyl-CoA Carboxylase Subunit Alpha)
rs1801186 is a single nucleotide polymorphism (SNP) in the PCCA gene, involved in propionate metabolism / mitochondrial metabolism. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1801186 variant?
rs1801186 is a SNP (single nucleotide polymorphism) in the PCCA (Propionyl-CoA Carboxylase Subunit Alpha) gene. It belongs to the Metabolic category and is part of the Mitochondrial Energy Production & PEM biological cluster. PCCA encodes the alpha subunit of propionyl-CoA carboxylase, which converts propionyl-CoA to methylmalonyl-CoA in mitochondria.
Biological role and pathway
This variant sits within the PCCA gene, which is involved in the propionate metabolism / mitochondrial metabolism pathway. Genes within the Mitochondrial Energy Production & PEM cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1801186 and Long COVID / ME-CFS research
Propionate metabolism intersects with B12 and methylmalonyl-CoA pathways; variants may affect organic acid metabolism and mitochondrial function in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: PCCA
rs1801186 is one of 1 known variant in the PCCA gene. To understand the full biological context of this variant, explore the parent gene page.
View PCCA gene page →Conditions studied in relation to rs1801186
Research into PCCA variants including rs1801186 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include PCCA and the rs1801186 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs1801186 variant in the PCCA gene?
rs1801186 is a single nucleotide polymorphism (SNP) located in the PCCA (Propionyl-CoA Carboxylase Subunit Alpha) gene, which is involved in propionate metabolism / mitochondrial metabolism. PCCA encodes the alpha subunit of propionyl-CoA carboxylase, which converts propionyl-CoA to methylmalonyl-CoA in mitochondria.
How may the rs1801186 variant relate to Long COVID or ME/CFS?
Propionate metabolism intersects with B12 and methylmalonyl-CoA pathways; variants may affect organic acid metabolism and mitochondrial function in Long COVID.
Can a consumer DNA test detect the rs1801186 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1801186 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for PCCA and its variants. This is not an exhaustive literature review.
- [1]PMID: 34316049
- [2]Nature Genetics
- [3]Metabolism