rs2479409
Variant in the PCSK9 gene (Proprotein Convertase Subtilisin/Kexin Type 9)
rs2479409 is a single nucleotide polymorphism (SNP) in the PCSK9 gene, involved in LDL receptor regulation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2479409 variant?
rs2479409 is a SNP (single nucleotide polymorphism) in the PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) gene. It belongs to the Metabolism category and is part of the Mitochondrial & Metabolic biological cluster. PCSK9 promotes LDLR degradation in lysosomes, reducing hepatic LDL uptake and increasing plasma LDL levels. Gain-of-function variants cause familial hypercholesterolemia; loss-of-function dramatically lowers LDL and cardiovascular risk.
Biological role and pathway
This variant sits within the PCSK9 gene, which is involved in the LDL receptor regulation pathway. Genes within the Mitochondrial & Metabolic cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2479409 and Long COVID / ME-CFS research
PCSK9 inhibitors are used for cardiovascular risk reduction and are being investigated in COVID-19. PCSK9 gain-of-function variants elevate LDL and cardiovascular risk; these may be relevant to the accelerated cardiovascular disease risk in Long COVID patients.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: PCSK9
rs2479409 is one of 3 known variants in the PCSK9 gene. To understand the full biological context of this variant, explore the parent gene page.
View PCSK9 gene page →Conditions studied in relation to rs2479409
Research into PCSK9 variants including rs2479409 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include PCSK9 and the rs2479409 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the PCSK9 gene
The following variants in PCSK9 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2479409 variant in the PCSK9 gene?
rs2479409 is a single nucleotide polymorphism (SNP) located in the PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) gene, which is involved in LDL receptor regulation. PCSK9 promotes LDLR degradation in lysosomes, reducing hepatic LDL uptake and increasing plasma LDL levels. Gain-of-function variants cause familial hypercholesterolemia; loss-of-function dramatically lowers LDL and cardiovascular risk.
How may the rs2479409 variant relate to Long COVID or ME/CFS?
PCSK9 inhibitors are used for cardiovascular risk reduction and are being investigated in COVID-19. PCSK9 gain-of-function variants elevate LDL and cardiovascular risk; these may be relevant to the accelerated cardiovascular disease risk in Long COVID patients.
Can a consumer DNA test detect the rs2479409 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2479409 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for PCSK9 and its variants. This is not an exhaustive literature review.
- [1]PMID: 26041305
- [2]New England Journal of Medicine
- [3]Nature