rs2735611
Variant in the PER1 gene (Period Circadian Regulator 1)
rs2735611 is a single nucleotide polymorphism (SNP) in the PER1 gene, involved in circadian clock machinery. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2735611 variant?
rs2735611 is a SNP (single nucleotide polymorphism) in the PER1 (Period Circadian Regulator 1) gene. It belongs to the Circadian category and is part of the Sleep & Circadian Rhythm biological cluster. PER1 encodes a core circadian clock protein that, with PER2 and CRY proteins, represses CLOCK/BMAL1 transcriptional activity.
Biological role and pathway
This variant sits within the PER1 gene, which is involved in the circadian clock machinery pathway. Genes within the Sleep & Circadian Rhythm cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2735611 and Long COVID / ME-CFS research
PER1 variants may affect the robustness of circadian rhythms and contribute to sleep and immune dysregulation in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: PER1
rs2735611 is one of 3 known variants in the PER1 gene. To understand the full biological context of this variant, explore the parent gene page.
View PER1 gene page →Conditions studied in relation to rs2735611
Research into PER1 variants including rs2735611 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include PER1 and the rs2735611 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the PER1 gene
The following variants in PER1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2735611 variant in the PER1 gene?
rs2735611 is a single nucleotide polymorphism (SNP) located in the PER1 (Period Circadian Regulator 1) gene, which is involved in circadian clock machinery. PER1 encodes a core circadian clock protein that, with PER2 and CRY proteins, represses CLOCK/BMAL1 transcriptional activity.
How may the rs2735611 variant relate to Long COVID or ME/CFS?
PER1 variants may affect the robustness of circadian rhythms and contribute to sleep and immune dysregulation in Long COVID.
Can a consumer DNA test detect the rs2735611 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2735611 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for PER1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32127339
- [2]Nature Genetics
- [3]Journal of Clinical Investigation