rs2304672
Variant in the PER2 gene (Period Circadian Regulator 2)
rs2304672 is a single nucleotide polymorphism (SNP) in the PER2 gene, involved in circadian clock. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2304672 variant?
rs2304672 is a SNP (single nucleotide polymorphism) in the PER2 (Period Circadian Regulator 2) gene. It belongs to the Circadian Rhythm category and is part of the Neurological & Sleep biological cluster. PER2 is a central component of the molecular circadian clock, interacting with CRY proteins to suppress CLOCK/BMAL1 transcription and maintain circadian periodicity across tissues.
Biological role and pathway
This variant sits within the PER2 gene, which is involved in the circadian clock pathway. Genes within the Neurological & Sleep cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2304672 and Long COVID / ME-CFS research
PER2 variants are associated with delayed sleep phase syndrome and altered immune rhythms. Long COVID patients show disrupted circadian biology that may be worsened by PER2 polymorphisms affecting recovery capacity.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: PER2
rs2304672 is one of 3 known variants in the PER2 gene. To understand the full biological context of this variant, explore the parent gene page.
View PER2 gene page →Conditions studied in relation to rs2304672
Research into PER2 variants including rs2304672 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include PER2 and the rs2304672 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the PER2 gene
The following variants in PER2 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2304672 variant in the PER2 gene?
rs2304672 is a single nucleotide polymorphism (SNP) located in the PER2 (Period Circadian Regulator 2) gene, which is involved in circadian clock. PER2 is a central component of the molecular circadian clock, interacting with CRY proteins to suppress CLOCK/BMAL1 transcription and maintain circadian periodicity across tissues.
How may the rs2304672 variant relate to Long COVID or ME/CFS?
PER2 variants are associated with delayed sleep phase syndrome and altered immune rhythms. Long COVID patients show disrupted circadian biology that may be worsened by PER2 polymorphisms affecting recovery capacity.
Can a consumer DNA test detect the rs2304672 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2304672 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for PER2 and its variants. This is not an exhaustive literature review.
- [1]PMID: 29078403
- [2]Cell
- [3]Genes & Development