rs10462021
Variant in the PER3 gene (Period Circadian Regulator 3)
rs10462021 is a single nucleotide polymorphism (SNP) in the PER3 gene, involved in circadian clock. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs10462021 variant?
rs10462021 is a SNP (single nucleotide polymorphism) in the PER3 (Period Circadian Regulator 3) gene. It belongs to the Circadian Rhythm category and is part of the Neurological & Sleep biological cluster. PER3 encodes a circadian clock component with a variable number tandem repeat (VNTR) polymorphism affecting sleep phenotypes. The 5-repeat allele is associated with morning preference while the 4-repeat allele associates with delayed sleep phase.
Biological role and pathway
This variant sits within the PER3 gene, which is involved in the circadian clock pathway. Genes within the Neurological & Sleep cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs10462021 and Long COVID / ME-CFS research
The PER3 VNTR polymorphism influences sleep duration, sleep homeostasis, and cognitive performance following sleep deprivation — all relevant to the sleep dysfunction and cognitive impairment characterizing Long COVID brain fog.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: PER3
rs10462021 is one of 3 known variants in the PER3 gene. To understand the full biological context of this variant, explore the parent gene page.
View PER3 gene page →Conditions studied in relation to rs10462021
Research into PER3 variants including rs10462021 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include PER3 and the rs10462021 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the PER3 gene
The following variants in PER3 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs10462021 variant in the PER3 gene?
rs10462021 is a single nucleotide polymorphism (SNP) located in the PER3 (Period Circadian Regulator 3) gene, which is involved in circadian clock. PER3 encodes a circadian clock component with a variable number tandem repeat (VNTR) polymorphism affecting sleep phenotypes. The 5-repeat allele is associated with morning preference while the 4-repeat allele associates with delayed sleep phase.
How may the rs10462021 variant relate to Long COVID or ME/CFS?
The PER3 VNTR polymorphism influences sleep duration, sleep homeostasis, and cognitive performance following sleep deprivation — all relevant to the sleep dysfunction and cognitive impairment characterizing Long COVID brain fog.
Can a consumer DNA test detect the rs10462021 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs10462021 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for PER3 and its variants. This is not an exhaustive literature review.
- [1]PMID: 12939611
- [2]Current Biology
- [3]Sleep