rs4272509
Variant in the PIEZO2 gene (Piezo Type Mechanosensitive Ion Channel Component 2)
rs4272509 is a single nucleotide polymorphism (SNP) in the PIEZO2 gene, involved in mechanosensory and proprioceptive signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs4272509 variant?
rs4272509 is a SNP (single nucleotide polymorphism) in the PIEZO2 (Piezo Type Mechanosensitive Ion Channel Component 2) gene. It belongs to the Pain Sensory category and is part of the Pain & Sensory Processing biological cluster. PIEZO2 encodes a mechanosensitive ion channel in sensory neurons essential for proprioception, touch discrimination, and pain.
Biological role and pathway
This variant sits within the PIEZO2 gene, which is involved in the mechanosensory and proprioceptive signaling pathway. Genes within the Pain & Sensory Processing cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs4272509 and Long COVID / ME-CFS research
PIEZO2 variants affecting mechanosensory signaling may contribute to allodynia and sensory abnormalities in Long COVID neuropathy.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: PIEZO2
rs4272509 is one of 1 known variant in the PIEZO2 gene. To understand the full biological context of this variant, explore the parent gene page.
View PIEZO2 gene page →Conditions studied in relation to rs4272509
Research into PIEZO2 variants including rs4272509 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include PIEZO2 and the rs4272509 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs4272509 variant in the PIEZO2 gene?
rs4272509 is a single nucleotide polymorphism (SNP) located in the PIEZO2 (Piezo Type Mechanosensitive Ion Channel Component 2) gene, which is involved in mechanosensory and proprioceptive signaling. PIEZO2 encodes a mechanosensitive ion channel in sensory neurons essential for proprioception, touch discrimination, and pain.
How may the rs4272509 variant relate to Long COVID or ME/CFS?
PIEZO2 variants affecting mechanosensory signaling may contribute to allodynia and sensory abnormalities in Long COVID neuropathy.
Can a consumer DNA test detect the rs4272509 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs4272509 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for PIEZO2 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32272069
- [2]Nature Genetics
- [3]Journal of Clinical Investigation