rs2699887

What is the rs2699887 variant?

rs2699887 is a SNP (single nucleotide polymorphism) in the PIK3CA (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha) gene. It belongs to the Signaling category and is part of the Metabolic Regulation biological cluster. PIK3CA encodes the alpha catalytic subunit of PI3-kinase, a central kinase in the PI3K/AKT/mTOR signaling pathway.

Biological role and pathway

This variant sits within the PIK3CA gene, which is involved in the PI3K-AKT-mTOR signaling pathway. Genes within the Metabolic Regulation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: PIK3CA

rs2699887 is one of 1 known variant in the PIK3CA gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs2699887

Research into PIK3CA variants including rs2699887 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include PIK3CA and the rs2699887 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions