rs1799889
Variant in the PLAT gene (Plasminogen Activator, Tissue Type)
rs1799889 is a single nucleotide polymorphism (SNP) in the PLAT gene, involved in fibrinolysis. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1799889 variant?
rs1799889 is a SNP (single nucleotide polymorphism) in the PLAT (Plasminogen Activator, Tissue Type) gene. It belongs to the Coagulation category and is part of the Coagulation & Vascular biological cluster. tPA (PLAT) converts plasminogen to plasmin to dissolve fibrin clots. It is the basis of thrombolytic therapy for stroke. Endothelial tPA release is triggered by stasis, thrombin, and bradykinin.
Biological role and pathway
This variant sits within the PLAT gene, which is involved in the fibrinolysis pathway. Genes within the Coagulation & Vascular cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1799889 and Long COVID / ME-CFS research
Impaired fibrinolysis contributes to persistent microthrombi in Long COVID. PLAT variants affecting tPA release or activity may reduce clot dissolution capacity, exacerbating the microthrombi-driven ischemia and vascular dysfunction underlying some Long COVID symptoms.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: PLAT
rs1799889 is one of 3 known variants in the PLAT gene. To understand the full biological context of this variant, explore the parent gene page.
View PLAT gene page →Conditions studied in relation to rs1799889
Research into PLAT variants including rs1799889 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include PLAT and the rs1799889 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the PLAT gene
The following variants in PLAT are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1799889 variant in the PLAT gene?
rs1799889 is a single nucleotide polymorphism (SNP) located in the PLAT (Plasminogen Activator, Tissue Type) gene, which is involved in fibrinolysis. tPA (PLAT) converts plasminogen to plasmin to dissolve fibrin clots. It is the basis of thrombolytic therapy for stroke. Endothelial tPA release is triggered by stasis, thrombin, and bradykinin.
How may the rs1799889 variant relate to Long COVID or ME/CFS?
Impaired fibrinolysis contributes to persistent microthrombi in Long COVID. PLAT variants affecting tPA release or activity may reduce clot dissolution capacity, exacerbating the microthrombi-driven ischemia and vascular dysfunction underlying some Long COVID symptoms.
Can a consumer DNA test detect the rs1799889 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1799889 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for PLAT and its variants. This is not an exhaustive literature review.
- [1]PMID: 32910905
- [2]Blood
- [3]Nature Medicine