rs3788015
Variant in the PLCG2 gene (Phospholipase C Gamma 2)
rs3788015 is a single nucleotide polymorphism (SNP) in the PLCG2 gene, involved in B cell signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs3788015 variant?
rs3788015 is a SNP (single nucleotide polymorphism) in the PLCG2 (Phospholipase C Gamma 2) gene. It belongs to the Adaptive Immunity category and is part of the Adaptive Immunity biological cluster. PLCγ2 is activated by BTK and other tyrosine kinases downstream of immune receptors to generate IP3 and DAG, mobilizing calcium and activating PKC. Gain-of-function variants cause PLCG2-associated antibody deficiency and immune dysregulation (PLAID/APLAID).
Biological role and pathway
This variant sits within the PLCG2 gene, which is involved in the B cell signaling pathway. Genes within the Adaptive Immunity cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs3788015 and Long COVID / ME-CFS research
PLCG2 variants influence B cell and mast cell activation. The common rs72689236 protective variant is associated with lower Alzheimer's risk through microglial effects. In Long COVID neuroinflammation, PLCγ2 signaling in microglia may be relevant.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: PLCG2
rs3788015 is one of 3 known variants in the PLCG2 gene. To understand the full biological context of this variant, explore the parent gene page.
View PLCG2 gene page →Conditions studied in relation to rs3788015
Research into PLCG2 variants including rs3788015 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include PLCG2 and the rs3788015 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the PLCG2 gene
The following variants in PLCG2 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs3788015 variant in the PLCG2 gene?
rs3788015 is a single nucleotide polymorphism (SNP) located in the PLCG2 (Phospholipase C Gamma 2) gene, which is involved in B cell signaling. PLCγ2 is activated by BTK and other tyrosine kinases downstream of immune receptors to generate IP3 and DAG, mobilizing calcium and activating PKC. Gain-of-function variants cause PLCG2-associated antibody deficiency and immune dysregulation (PLAID/APLAID).
How may the rs3788015 variant relate to Long COVID or ME/CFS?
PLCG2 variants influence B cell and mast cell activation. The common rs72689236 protective variant is associated with lower Alzheimer's risk through microglial effects. In Long COVID neuroinflammation, PLCγ2 signaling in microglia may be relevant.
Can a consumer DNA test detect the rs3788015 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs3788015 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for PLCG2 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32066874
- [2]Nature Genetics
- [3]Journal of Experimental Medicine