rs2232707
Variant in the PLG gene (Plasminogen)
rs2232707 is a single nucleotide polymorphism (SNP) in the PLG gene, involved in fibrinolysis. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2232707 variant?
rs2232707 is a SNP (single nucleotide polymorphism) in the PLG (Plasminogen) gene. It belongs to the Coagulation category and is part of the Coagulation & Vascular biological cluster. Plasminogen is the zymogen of plasmin, the primary fibrinolytic enzyme. It is activated by tPA and urokinase (uPA) to dissolve fibrin clots and degrade ECM. Congenital plasminogen deficiency causes ligneous conjunctivitis.
Biological role and pathway
This variant sits within the PLG gene, which is involved in the fibrinolysis pathway. Genes within the Coagulation & Vascular cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2232707 and Long COVID / ME-CFS research
Impaired plasminogen activation and fibrinolysis are documented in Long COVID patients. PLG variants affecting plasminogen levels or activation susceptibility may impair fibrin clearance and contribute to the persistent microthrombi state in Long COVID vascular disease.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: PLG
rs2232707 is one of 3 known variants in the PLG gene. To understand the full biological context of this variant, explore the parent gene page.
View PLG gene page →Conditions studied in relation to rs2232707
Research into PLG variants including rs2232707 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include PLG and the rs2232707 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the PLG gene
The following variants in PLG are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2232707 variant in the PLG gene?
rs2232707 is a single nucleotide polymorphism (SNP) located in the PLG (Plasminogen) gene, which is involved in fibrinolysis. Plasminogen is the zymogen of plasmin, the primary fibrinolytic enzyme. It is activated by tPA and urokinase (uPA) to dissolve fibrin clots and degrade ECM. Congenital plasminogen deficiency causes ligneous conjunctivitis.
How may the rs2232707 variant relate to Long COVID or ME/CFS?
Impaired plasminogen activation and fibrinolysis are documented in Long COVID patients. PLG variants affecting plasminogen levels or activation susceptibility may impair fibrin clearance and contribute to the persistent microthrombi state in Long COVID vascular disease.
Can a consumer DNA test detect the rs2232707 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2232707 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for PLG and its variants. This is not an exhaustive literature review.
- [1]PMID: 30860547
- [2]Blood
- [3]Nature Medicine