rs1052700
Variant in the PLIN1 gene (Perilipin 1)
rs1052700 is a single nucleotide polymorphism (SNP) in the PLIN1 gene, involved in lipid droplet regulation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1052700 variant?
rs1052700 is a SNP (single nucleotide polymorphism) in the PLIN1 (Perilipin 1) gene. It belongs to the Lipid Metabolism category and is part of the Lipid Metabolism biological cluster. PLIN1 encodes perilipin 1, the major coat protein of lipid droplets in adipocytes, regulating lipolysis and fat mobilization.
Biological role and pathway
This variant sits within the PLIN1 gene, which is involved in the lipid droplet regulation pathway. Genes within the Lipid Metabolism cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1052700 and Long COVID / ME-CFS research
Lipid droplet dynamics are relevant to viral replication environments and immune cell activation; PLIN1 variants may influence metabolic features of Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: PLIN1
rs1052700 is one of 2 known variants in the PLIN1 gene. To understand the full biological context of this variant, explore the parent gene page.
View PLIN1 gene page →Conditions studied in relation to rs1052700
Research into PLIN1 variants including rs1052700 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include PLIN1 and the rs1052700 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the PLIN1 gene
The following variants in PLIN1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1052700 variant in the PLIN1 gene?
rs1052700 is a single nucleotide polymorphism (SNP) located in the PLIN1 (Perilipin 1) gene, which is involved in lipid droplet regulation. PLIN1 encodes perilipin 1, the major coat protein of lipid droplets in adipocytes, regulating lipolysis and fat mobilization.
How may the rs1052700 variant relate to Long COVID or ME/CFS?
Lipid droplet dynamics are relevant to viral replication environments and immune cell activation; PLIN1 variants may influence metabolic features of Long COVID.
Can a consumer DNA test detect the rs1052700 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1052700 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for PLIN1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33153018
- [2]Nature Genetics
- [3]Journal of Clinical Investigation