rs6713532
Variant in the POMC gene (Proopiomelanocortin)
rs6713532 is a single nucleotide polymorphism (SNP) in the POMC gene, involved in HPA axis / melanocortin signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs6713532 variant?
rs6713532 is a SNP (single nucleotide polymorphism) in the POMC (Proopiomelanocortin) gene. It belongs to the Neuroendocrine category and is part of the Autonomic Nervous System biological cluster. POMC encodes proopiomelanocortin, the precursor peptide cleaved to ACTH, alpha-MSH, beta-endorphin, and other neuropeptides.
Biological role and pathway
This variant sits within the POMC gene, which is involved in the HPA axis / melanocortin signaling pathway. Genes within the Autonomic Nervous System cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs6713532 and Long COVID / ME-CFS research
POMC-derived beta-endorphin is an endogenous opioid; variants affecting ACTH secretion and melanocortin signaling may influence HPA axis function and fatigue in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: POMC
rs6713532 is one of 2 known variants in the POMC gene. To understand the full biological context of this variant, explore the parent gene page.
View POMC gene page →Conditions studied in relation to rs6713532
Research into POMC variants including rs6713532 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include POMC and the rs6713532 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the POMC gene
The following variants in POMC are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs6713532 variant in the POMC gene?
rs6713532 is a single nucleotide polymorphism (SNP) located in the POMC (Proopiomelanocortin) gene, which is involved in HPA axis / melanocortin signaling. POMC encodes proopiomelanocortin, the precursor peptide cleaved to ACTH, alpha-MSH, beta-endorphin, and other neuropeptides.
How may the rs6713532 variant relate to Long COVID or ME/CFS?
POMC-derived beta-endorphin is an endogenous opioid; variants affecting ACTH secretion and melanocortin signaling may influence HPA axis function and fatigue in Long COVID.
Can a consumer DNA test detect the rs6713532 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs6713532 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for POMC and its variants. This is not an exhaustive literature review.
- [1]PMID: 33664986
- [2]Nature Genetics
- [3]Cell