rs1053049
Variant in the PPARD gene (Peroxisome Proliferator Activated Receptor Delta)
rs1053049 is a single nucleotide polymorphism (SNP) in the PPARD gene, involved in fatty acid oxidation / muscle metabolism. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1053049 variant?
rs1053049 is a SNP (single nucleotide polymorphism) in the PPARD (Peroxisome Proliferator Activated Receptor Delta) gene. It belongs to the Metabolic category and is part of the Mitochondrial Energy Production & PEM biological cluster. PPARD encodes PPAR-delta/beta, which regulates fatty acid oxidation and energy utilization particularly in skeletal muscle.
Biological role and pathway
This variant sits within the PPARD gene, which is involved in the fatty acid oxidation / muscle metabolism pathway. Genes within the Mitochondrial Energy Production & PEM cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1053049 and Long COVID / ME-CFS research
PPARD regulates energy metabolism in muscle; variants may affect exercise capacity and susceptibility to post-exertional metabolic dysfunction in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: PPARD
rs1053049 is one of 2 known variants in the PPARD gene. To understand the full biological context of this variant, explore the parent gene page.
View PPARD gene page →Conditions studied in relation to rs1053049
Research into PPARD variants including rs1053049 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include PPARD and the rs1053049 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the PPARD gene
The following variants in PPARD are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1053049 variant in the PPARD gene?
rs1053049 is a single nucleotide polymorphism (SNP) located in the PPARD (Peroxisome Proliferator Activated Receptor Delta) gene, which is involved in fatty acid oxidation / muscle metabolism. PPARD encodes PPAR-delta/beta, which regulates fatty acid oxidation and energy utilization particularly in skeletal muscle.
How may the rs1053049 variant relate to Long COVID or ME/CFS?
PPARD regulates energy metabolism in muscle; variants may affect exercise capacity and susceptibility to post-exertional metabolic dysfunction in Long COVID.
Can a consumer DNA test detect the rs1053049 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1053049 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for PPARD and its variants. This is not an exhaustive literature review.
- [1]PMID: 34316049
- [2]Nature Genetics
- [3]Cell Metabolism