rs1801282
Variant in the PPARG gene (Peroxisome Proliferator-Activated Receptor Gamma)
rs1801282 is a single nucleotide polymorphism (SNP) in the PPARG gene, involved in adipogenesis and metabolic regulation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1801282 variant?
rs1801282 is a SNP (single nucleotide polymorphism) in the PPARG (Peroxisome Proliferator-Activated Receptor Gamma) gene. It belongs to the Metabolic category and is part of the Metabolic Regulation biological cluster. PPARG encodes the nuclear receptor that regulates adipogenesis, insulin sensitivity, and inflammatory gene expression.
Biological role and pathway
This variant sits within the PPARG gene, which is involved in the adipogenesis and metabolic regulation pathway. Genes within the Metabolic Regulation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1801282 and Long COVID / ME-CFS research
PPARG variants may influence metabolic dysregulation and adipose tissue inflammation associated with post-acute COVID metabolic syndrome.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: PPARG
rs1801282 is one of 2 known variants in the PPARG gene. To understand the full biological context of this variant, explore the parent gene page.
View PPARG gene page →Conditions studied in relation to rs1801282
Research into PPARG variants including rs1801282 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include PPARG and the rs1801282 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the PPARG gene
The following variants in PPARG are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1801282 variant in the PPARG gene?
rs1801282 is a single nucleotide polymorphism (SNP) located in the PPARG (Peroxisome Proliferator-Activated Receptor Gamma) gene, which is involved in adipogenesis and metabolic regulation. PPARG encodes the nuclear receptor that regulates adipogenesis, insulin sensitivity, and inflammatory gene expression.
How may the rs1801282 variant relate to Long COVID or ME/CFS?
PPARG variants may influence metabolic dysregulation and adipose tissue inflammation associated with post-acute COVID metabolic syndrome.
Can a consumer DNA test detect the rs1801282 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1801282 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for PPARG and its variants. This is not an exhaustive literature review.
- [1]PMID: 32735956
- [2]Nature Genetics
- [3]Journal of Clinical Investigation