rs8192678
Variant in the PPARGC1A gene (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1 Alpha)
rs8192678 is a single nucleotide polymorphism (SNP) in the PPARGC1A gene, involved in mitochondrial biogenesis. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs8192678 variant?
rs8192678 is a SNP (single nucleotide polymorphism) in the PPARGC1A (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1 Alpha) gene. It belongs to the Mitochondrial category and is part of the Mitochondrial Energy Production & PEM biological cluster. PPARGC1A is the master regulator of mitochondrial biogenesis and oxidative metabolism.
Biological role and pathway
This variant sits within the PPARGC1A gene, which is involved in the mitochondrial biogenesis pathway. Genes within the Mitochondrial Energy Production & PEM cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs8192678 and Long COVID / ME-CFS research
Impaired PPARGC1A function may underlie mitochondrial dysfunction and reduced energy production observed in Long COVID and ME/CFS.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: PPARGC1A
rs8192678 is one of 1 known variant in the PPARGC1A gene. To understand the full biological context of this variant, explore the parent gene page.
View PPARGC1A gene page →Conditions studied in relation to rs8192678
Research into PPARGC1A variants including rs8192678 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include PPARGC1A and the rs8192678 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs8192678 variant in the PPARGC1A gene?
rs8192678 is a single nucleotide polymorphism (SNP) located in the PPARGC1A (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1 Alpha) gene, which is involved in mitochondrial biogenesis. PPARGC1A is the master regulator of mitochondrial biogenesis and oxidative metabolism.
How may the rs8192678 variant relate to Long COVID or ME/CFS?
Impaired PPARGC1A function may underlie mitochondrial dysfunction and reduced energy production observed in Long COVID and ME/CFS.
Can a consumer DNA test detect the rs8192678 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs8192678 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for PPARGC1A and its variants. This is not an exhaustive literature review.
- [1]PMID: 32735956
- [2]Nature Genetics
- [3]Journal of Clinical Investigation