rs6850

Variant in the PPIA gene (Peptidylprolyl Isomerase A (Cyclophilin A))

rs6850 is a single nucleotide polymorphism (SNP) in the PPIA gene, involved in protein folding / SARS-CoV-2 facilitation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.

This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.

What is the rs6850 variant?

rs6850 is a SNP (single nucleotide polymorphism) in the PPIA (Peptidylprolyl Isomerase A (Cyclophilin A)) gene. It belongs to the Antiviral category and is part of the Viral Defense & Interferon Response biological cluster. PPIA encodes cyclophilin A, a peptidyl-prolyl isomerase that facilitates protein folding and is implicated in CD147-mediated viral entry and inflammatory signaling.

Biological role and pathway

This variant sits within the PPIA gene, which is involved in the protein folding / SARS-CoV-2 facilitation pathway. Genes within the Viral Defense & Interferon Response cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

rs6850 and Long COVID / ME-CFS research

Cyclophilin A secreted during inflammation binds CD147 and promotes cell entry; variants may affect SARS-CoV-2 CD147-dependent entry pathways and inflammatory cascades in Long COVID.

This information is based on published research and does not constitute medical advice. See references below.

Parent gene: PPIA

rs6850 is one of 1 known variant in the PPIA gene. To understand the full biological context of this variant, explore the parent gene page.

View PPIA gene page →

Conditions studied in relation to rs6850

Research into PPIA variants including rs6850 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Long Covid Viral Entry Inflammation

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include PPIA and the rs6850 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions

What is the rs6850 variant in the PPIA gene?

rs6850 is a single nucleotide polymorphism (SNP) located in the PPIA (Peptidylprolyl Isomerase A (Cyclophilin A)) gene, which is involved in protein folding / SARS-CoV-2 facilitation. PPIA encodes cyclophilin A, a peptidyl-prolyl isomerase that facilitates protein folding and is implicated in CD147-mediated viral entry and inflammatory signaling.

How may the rs6850 variant relate to Long COVID or ME/CFS?

Cyclophilin A secreted during inflammation binds CD147 and promotes cell entry; variants may affect SARS-CoV-2 CD147-dependent entry pathways and inflammatory cascades in Long COVID.

Can a consumer DNA test detect the rs6850 variant?

Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.

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Find out if you carry the rs6850 variant

Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.

Get Your Personalised DNA Report

Informational and educational only · Not a diagnostic tool · GDPR compliant

References

The following publications were used in compiling the research context for PPIA and its variants. This is not an exhaustive literature review.

[1]PMID: 32217835
[2]Nature Genetics
[3]Cell