rs2796498

What is the rs2796498 variant?

rs2796498 is a SNP (single nucleotide polymorphism) in the PRKAA2 (Protein Kinase AMP-Activated Catalytic Subunit Alpha 2) gene. It belongs to the Metabolic category and is part of the Metabolic Regulation biological cluster. PRKAA2 encodes AMPK alpha-2, the catalytic subunit that senses energy depletion and activates catabolic processes to restore ATP.

Biological role and pathway

This variant sits within the PRKAA2 gene, which is involved in the AMPK metabolic sensing pathway. Genes within the Metabolic Regulation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: PRKAA2

rs2796498 is one of 1 known variant in the PRKAA2 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs2796498

Research into PRKAA2 variants including rs2796498 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include PRKAA2 and the rs2796498 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions