rs2169960

What is the rs2169960 variant?

rs2169960 is a SNP (single nucleotide polymorphism) in the PRKAR1A (Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha) gene. It belongs to the Signaling category and is part of the Metabolic Regulation biological cluster. PRKAR1A encodes the regulatory subunit of PKA that normally inhibits the catalytic subunit; mutations cause Carney complex.

Biological role and pathway

This variant sits within the PRKAR1A gene, which is involved in the cAMP/PKA signaling regulation pathway. Genes within the Metabolic Regulation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: PRKAR1A

rs2169960 is one of 1 known variant in the PRKAR1A gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs2169960

Research into PRKAR1A variants including rs2169960 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include PRKAR1A and the rs2169960 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions