rs34424986

What is the rs34424986 variant?

rs34424986 is a SNP (single nucleotide polymorphism) in the PRKN (Parkin RBR E3 Ubiquitin Protein Ligase) gene. It belongs to the Mitochondrial category and is part of the Mitochondrial Energy Production & PEM biological cluster. PRKN encodes Parkin, an E3 ubiquitin ligase that, together with PINK1, tags dysfunctional mitochondria for selective autophagy.

Biological role and pathway

This variant sits within the PRKN gene, which is involved in the mitophagy regulation pathway. Genes within the Mitochondrial Energy Production & PEM cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: PRKN

rs34424986 is one of 2 known variants in the PRKN gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs34424986

Research into PRKN variants including rs34424986 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include PRKN and the rs34424986 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the PRKN gene

The following variants in PRKN are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions