rs2069911
Variant in the PROC gene (Protein C)
rs2069911 is a single nucleotide polymorphism (SNP) in the PROC gene, involved in anticoagulation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2069911 variant?
rs2069911 is a SNP (single nucleotide polymorphism) in the PROC (Protein C) gene. It belongs to the Coagulation category and is part of the Coagulation & Vascular biological cluster. Protein C is the zymogen of activated protein C (APC), the major physiological anticoagulant that inactivates factors Va and VIIIa. It requires vitamin K-dependent carboxylation and is activated by the thrombin-thrombomodulin complex.
Biological role and pathway
This variant sits within the PROC gene, which is involved in the anticoagulation pathway. Genes within the Coagulation & Vascular cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2069911 and Long COVID / ME-CFS research
Protein C deficiency predisposes to venous thromboembolism. Acquired protein C depletion in COVID-19 coagulopathy may be compounded by PROC variants reducing baseline protein C levels, increasing thrombotic risk in Long COVID patients.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: PROC
rs2069911 is one of 3 known variants in the PROC gene. To understand the full biological context of this variant, explore the parent gene page.
View PROC gene page →Conditions studied in relation to rs2069911
Research into PROC variants including rs2069911 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include PROC and the rs2069911 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the PROC gene
The following variants in PROC are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2069911 variant in the PROC gene?
rs2069911 is a single nucleotide polymorphism (SNP) located in the PROC (Protein C) gene, which is involved in anticoagulation. Protein C is the zymogen of activated protein C (APC), the major physiological anticoagulant that inactivates factors Va and VIIIa. It requires vitamin K-dependent carboxylation and is activated by the thrombin-thrombomodulin complex.
How may the rs2069911 variant relate to Long COVID or ME/CFS?
Protein C deficiency predisposes to venous thromboembolism. Acquired protein C depletion in COVID-19 coagulopathy may be compounded by PROC variants reducing baseline protein C levels, increasing thrombotic risk in Long COVID patients.
Can a consumer DNA test detect the rs2069911 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2069911 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for PROC and its variants. This is not an exhaustive literature review.
- [1]PMID: 26785756
- [2]Blood
- [3]New England Journal of Medicine