rs156397
Variant in the PTAFR gene (Platelet Activating Factor Receptor)
rs156397 is a single nucleotide polymorphism (SNP) in the PTAFR gene, involved in platelet activating factor / inflammation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs156397 variant?
rs156397 is a SNP (single nucleotide polymorphism) in the PTAFR (Platelet Activating Factor Receptor) gene. It belongs to the Immune Signaling category and is part of the Coagulation & Microcirculation biological cluster. PTAFR encodes the receptor for platelet activating factor (PAF), a potent inflammatory mediator that activates platelets, neutrophils, and endothelial cells.
Biological role and pathway
This variant sits within the PTAFR gene, which is involved in the platelet activating factor / inflammation pathway. Genes within the Coagulation & Microcirculation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs156397 and Long COVID / ME-CFS research
PAF-receptor activation contributes to platelet-endothelial interactions and inflammatory signaling in COVID-19; variants may affect platelet activation and endothelial inflammation in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: PTAFR
rs156397 is one of 1 known variant in the PTAFR gene. To understand the full biological context of this variant, explore the parent gene page.
View PTAFR gene page →Conditions studied in relation to rs156397
Research into PTAFR variants including rs156397 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include PTAFR and the rs156397 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs156397 variant in the PTAFR gene?
rs156397 is a single nucleotide polymorphism (SNP) located in the PTAFR (Platelet Activating Factor Receptor) gene, which is involved in platelet activating factor / inflammation. PTAFR encodes the receptor for platelet activating factor (PAF), a potent inflammatory mediator that activates platelets, neutrophils, and endothelial cells.
How may the rs156397 variant relate to Long COVID or ME/CFS?
PAF-receptor activation contributes to platelet-endothelial interactions and inflammatory signaling in COVID-19; variants may affect platelet activation and endothelial inflammation in Long COVID.
Can a consumer DNA test detect the rs156397 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs156397 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for PTAFR and its variants. This is not an exhaustive literature review.
- [1]PMID: 32966261
- [2]Nature Genetics
- [3]Journal of Biological Chemistry