rs701848
Variant in the PTEN gene (Phosphatase And Tensin Homolog)
rs701848 is a single nucleotide polymorphism (SNP) in the PTEN gene, involved in PI3K-AKT negative regulation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs701848 variant?
rs701848 is a SNP (single nucleotide polymorphism) in the PTEN (Phosphatase And Tensin Homolog) gene. It belongs to the Signaling category and is part of the Immune System & Inflammation biological cluster. PTEN is a phosphatase that antagonizes PI3K signaling by dephosphorylating PIP3, serving as a tumor suppressor and immune regulator.
Biological role and pathway
This variant sits within the PTEN gene, which is involved in the PI3K-AKT negative regulation pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs701848 and Long COVID / ME-CFS research
PTEN regulates immune cell activation and T cell function; variants may affect PI3K-AKT signaling balance and immune homeostasis in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: PTEN
rs701848 is one of 2 known variants in the PTEN gene. To understand the full biological context of this variant, explore the parent gene page.
View PTEN gene page →Conditions studied in relation to rs701848
Research into PTEN variants including rs701848 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include PTEN and the rs701848 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the PTEN gene
The following variants in PTEN are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs701848 variant in the PTEN gene?
rs701848 is a single nucleotide polymorphism (SNP) located in the PTEN (Phosphatase And Tensin Homolog) gene, which is involved in PI3K-AKT negative regulation. PTEN is a phosphatase that antagonizes PI3K signaling by dephosphorylating PIP3, serving as a tumor suppressor and immune regulator.
How may the rs701848 variant relate to Long COVID or ME/CFS?
PTEN regulates immune cell activation and T cell function; variants may affect PI3K-AKT signaling balance and immune homeostasis in Long COVID.
Can a consumer DNA test detect the rs701848 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs701848 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for PTEN and its variants. This is not an exhaustive literature review.
- [1]PMID: 33153018
- [2]Nature Genetics
- [3]Cell