rs20417
Variant in the PTGS2 gene (Prostaglandin-Endoperoxide Synthase 2 (COX-2))
rs20417 is a single nucleotide polymorphism (SNP) in the PTGS2 gene, involved in prostaglandin synthesis. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs20417 variant?
rs20417 is a SNP (single nucleotide polymorphism) in the PTGS2 (Prostaglandin-Endoperoxide Synthase 2 (COX-2)) gene. It belongs to the Inflammation category and is part of the Inflammation Mediators biological cluster. PTGS2 encodes cyclooxygenase-2 (COX-2), the inducible enzyme catalyzing the first step of prostaglandin synthesis from arachidonic acid.
Biological role and pathway
This variant sits within the PTGS2 gene, which is involved in the prostaglandin synthesis pathway. Genes within the Inflammation Mediators cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs20417 and Long COVID / ME-CFS research
COX-2-driven prostaglandin production contributes to fever, pain, and vascular inflammation; variants may influence inflammatory resolution in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: PTGS2
rs20417 is one of 2 known variants in the PTGS2 gene. To understand the full biological context of this variant, explore the parent gene page.
View PTGS2 gene page →Conditions studied in relation to rs20417
Research into PTGS2 variants including rs20417 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include PTGS2 and the rs20417 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the PTGS2 gene
The following variants in PTGS2 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs20417 variant in the PTGS2 gene?
rs20417 is a single nucleotide polymorphism (SNP) located in the PTGS2 (Prostaglandin-Endoperoxide Synthase 2 (COX-2)) gene, which is involved in prostaglandin synthesis. PTGS2 encodes cyclooxygenase-2 (COX-2), the inducible enzyme catalyzing the first step of prostaglandin synthesis from arachidonic acid.
How may the rs20417 variant relate to Long COVID or ME/CFS?
COX-2-driven prostaglandin production contributes to fever, pain, and vascular inflammation; variants may influence inflammatory resolution in Long COVID.
Can a consumer DNA test detect the rs20417 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs20417 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for PTGS2 and its variants. This is not an exhaustive literature review.
- [1]PMID: 34316049
- [2]Nature Genetics
- [3]Journal of Clinical Investigation