rs7234029
Variant in the PTPN2 gene (Protein Tyrosine Phosphatase Non-Receptor Type 2)
rs7234029 is a single nucleotide polymorphism (SNP) in the PTPN2 gene, involved in JAK-STAT regulation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs7234029 variant?
rs7234029 is a SNP (single nucleotide polymorphism) in the PTPN2 (Protein Tyrosine Phosphatase Non-Receptor Type 2) gene. It belongs to the Adaptive Immunity category and is part of the Adaptive Immunity biological cluster. PTPN2 (TC-PTP) dephosphorylates JAK1, JAK3, STAT1, and STAT3, negatively regulating cytokine and growth factor signaling. It is a major autoimmune susceptibility gene and a target of checkpoint immunotherapy approaches.
Biological role and pathway
This variant sits within the PTPN2 gene, which is involved in the JAK-STAT regulation pathway. Genes within the Adaptive Immunity cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs7234029 and Long COVID / ME-CFS research
PTPN2 variants increase susceptibility to inflammatory bowel disease, celiac disease, and type 1 diabetes. Its role in dampening interferon and cytokine signals means PTPN2 variants may impair resolution of Long COVID interferon responses.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: PTPN2
rs7234029 is one of 3 known variants in the PTPN2 gene. To understand the full biological context of this variant, explore the parent gene page.
View PTPN2 gene page →Conditions studied in relation to rs7234029
Research into PTPN2 variants including rs7234029 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include PTPN2 and the rs7234029 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the PTPN2 gene
The following variants in PTPN2 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs7234029 variant in the PTPN2 gene?
rs7234029 is a single nucleotide polymorphism (SNP) located in the PTPN2 (Protein Tyrosine Phosphatase Non-Receptor Type 2) gene, which is involved in JAK-STAT regulation. PTPN2 (TC-PTP) dephosphorylates JAK1, JAK3, STAT1, and STAT3, negatively regulating cytokine and growth factor signaling. It is a major autoimmune susceptibility gene and a target of checkpoint immunotherapy approaches.
How may the rs7234029 variant relate to Long COVID or ME/CFS?
PTPN2 variants increase susceptibility to inflammatory bowel disease, celiac disease, and type 1 diabetes. Its role in dampening interferon and cytokine signals means PTPN2 variants may impair resolution of Long COVID interferon responses.
Can a consumer DNA test detect the rs7234029 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs7234029 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for PTPN2 and its variants. This is not an exhaustive literature review.
- [1]PMID: 27959929
- [2]Nature Genetics
- [3]Immunity