rs4241160

What is the rs4241160 variant?

rs4241160 is a SNP (single nucleotide polymorphism) in the PYCARD (PYD and CARD Domain Containing (ASC)) gene. It belongs to the Innate Immunity category and is part of the Innate Immunity & Pattern Recognition biological cluster. PYCARD encodes ASC, the inflammasome adaptor protein that bridges sensor proteins like NLRP3 to pro-caspase-1 for activation.

Biological role and pathway

This variant sits within the PYCARD gene, which is involved in the inflammasome assembly pathway. Genes within the Innate Immunity & Pattern Recognition cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: PYCARD

rs4241160 is one of 1 known variant in the PYCARD gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs4241160

Research into PYCARD variants including rs4241160 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include PYCARD and the rs4241160 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions