rs2033974

What is the rs2033974 variant?

rs2033974 is a SNP (single nucleotide polymorphism) in the RAG1 (Recombination Activating Gene 1) gene. It belongs to the Lymphocyte category and is part of the Lymphocyte Biology biological cluster. RAG1 encodes a component of the RAG recombinase that generates diverse T cell receptor and B cell receptor repertoires through V(D)J recombination.

Biological role and pathway

This variant sits within the RAG1 gene, which is involved in the V(D)J recombination pathway. Genes within the Lymphocyte Biology cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: RAG1

rs2033974 is one of 1 known variant in the RAG1 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs2033974

Research into RAG1 variants including rs2033974 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include RAG1 and the rs2033974 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions