rs3219175
Variant in the RETN gene (Resistin)
rs3219175 is a single nucleotide polymorphism (SNP) in the RETN gene, involved in adipokine / insulin resistance. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs3219175 variant?
rs3219175 is a SNP (single nucleotide polymorphism) in the RETN (Resistin) gene. It belongs to the Neuroendocrine category and is part of the Metabolic Regulation biological cluster. RETN encodes resistin, an adipokine implicated in insulin resistance and inflammation, expressed by macrophages in humans.
Biological role and pathway
This variant sits within the RETN gene, which is involved in the adipokine / insulin resistance pathway. Genes within the Metabolic Regulation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs3219175 and Long COVID / ME-CFS research
Resistin is pro-inflammatory and elevated in COVID-19 critical illness; RETN variants may affect metabolic inflammation and insulin resistance in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: RETN
rs3219175 is one of 2 known variants in the RETN gene. To understand the full biological context of this variant, explore the parent gene page.
View RETN gene page →Conditions studied in relation to rs3219175
Research into RETN variants including rs3219175 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include RETN and the rs3219175 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the RETN gene
The following variants in RETN are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs3219175 variant in the RETN gene?
rs3219175 is a single nucleotide polymorphism (SNP) located in the RETN (Resistin) gene, which is involved in adipokine / insulin resistance. RETN encodes resistin, an adipokine implicated in insulin resistance and inflammation, expressed by macrophages in humans.
How may the rs3219175 variant relate to Long COVID or ME/CFS?
Resistin is pro-inflammatory and elevated in COVID-19 critical illness; RETN variants may affect metabolic inflammation and insulin resistance in Long COVID.
Can a consumer DNA test detect the rs3219175 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs3219175 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for RETN and its variants. This is not an exhaustive literature review.
- [1]PMID: 33153018
- [2]Nature Genetics
- [3]Diabetes