rs2583957
Variant in the RIPK3 gene (Receptor Interacting Serine/Threonine Kinase 3)
rs2583957 is a single nucleotide polymorphism (SNP) in the RIPK3 gene, involved in necroptosis / programmed necrosis. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2583957 variant?
rs2583957 is a SNP (single nucleotide polymorphism) in the RIPK3 (Receptor Interacting Serine/Threonine Kinase 3) gene. It belongs to the Immune Signaling category and is part of the Immune System & Inflammation biological cluster. RIPK3 encodes a kinase that drives necroptotic cell death by phosphorylating MLKL, releasing DAMPs and amplifying inflammation.
Biological role and pathway
This variant sits within the RIPK3 gene, which is involved in the necroptosis / programmed necrosis pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2583957 and Long COVID / ME-CFS research
RIPK3-driven necroptosis is activated in COVID-19 and releases inflammatory mediators; variants may affect necroptosis threshold and tissue damage in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: RIPK3
rs2583957 is one of 1 known variant in the RIPK3 gene. To understand the full biological context of this variant, explore the parent gene page.
View RIPK3 gene page →Conditions studied in relation to rs2583957
Research into RIPK3 variants including rs2583957 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include RIPK3 and the rs2583957 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs2583957 variant in the RIPK3 gene?
rs2583957 is a single nucleotide polymorphism (SNP) located in the RIPK3 (Receptor Interacting Serine/Threonine Kinase 3) gene, which is involved in necroptosis / programmed necrosis. RIPK3 encodes a kinase that drives necroptotic cell death by phosphorylating MLKL, releasing DAMPs and amplifying inflammation.
How may the rs2583957 variant relate to Long COVID or ME/CFS?
RIPK3-driven necroptosis is activated in COVID-19 and releases inflammatory mediators; variants may affect necroptosis threshold and tissue damage in Long COVID.
Can a consumer DNA test detect the rs2583957 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2583957 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for RIPK3 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33398161
- [2]Nature Immunology
- [3]Cell