rs486907
Variant in the RNASEL gene (Ribonuclease L)
rs486907 is a single nucleotide polymorphism (SNP) in the RNASEL gene, involved in OAS/RNase L antiviral pathway. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs486907 variant?
rs486907 is a SNP (single nucleotide polymorphism) in the RNASEL (Ribonuclease L) gene. It belongs to the Antiviral category and is part of the Viral Defense & Interferon Response biological cluster. RNASEL encodes ribonuclease L, the terminal effector of the OAS/RNase L antiviral pathway that degrades cellular and viral RNA.
Biological role and pathway
This variant sits within the RNASEL gene, which is involved in the OAS/RNase L antiviral pathway pathway. Genes within the Viral Defense & Interferon Response cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs486907 and Long COVID / ME-CFS research
RNase L activation by viral dsRNA degrades viral genomes; variants may affect viral clearance efficiency and potentially contribute to viral persistence in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: RNASEL
rs486907 is one of 2 known variants in the RNASEL gene. To understand the full biological context of this variant, explore the parent gene page.
View RNASEL gene page →Conditions studied in relation to rs486907
Research into RNASEL variants including rs486907 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include RNASEL and the rs486907 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the RNASEL gene
The following variants in RNASEL are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs486907 variant in the RNASEL gene?
rs486907 is a single nucleotide polymorphism (SNP) located in the RNASEL (Ribonuclease L) gene, which is involved in OAS/RNase L antiviral pathway. RNASEL encodes ribonuclease L, the terminal effector of the OAS/RNase L antiviral pathway that degrades cellular and viral RNA.
How may the rs486907 variant relate to Long COVID or ME/CFS?
RNase L activation by viral dsRNA degrades viral genomes; variants may affect viral clearance efficiency and potentially contribute to viral persistence in Long COVID.
Can a consumer DNA test detect the rs486907 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs486907 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for RNASEL and its variants. This is not an exhaustive literature review.
- [1]PMID: 34385711
- [2]Nature Genetics
- [3]Journal of Immunology