rs11639084
Variant in the RORA gene (RAR Related Orphan Receptor A)
rs11639084 is a single nucleotide polymorphism (SNP) in the RORA gene, involved in circadian clock. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs11639084 variant?
rs11639084 is a SNP (single nucleotide polymorphism) in the RORA (RAR Related Orphan Receptor A) gene. It belongs to the Circadian Rhythm category and is part of the Neurological & Sleep biological cluster. RORA is a nuclear receptor that positively regulates BMAL1 transcription as part of the secondary circadian loop. It also has roles in neuroprotection, immunity, and cholesterol metabolism.
Biological role and pathway
This variant sits within the RORA gene, which is involved in the circadian clock pathway. Genes within the Neurological & Sleep cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs11639084 and Long COVID / ME-CFS research
RORA variants are associated with autism spectrum disorder and sleep problems. In Long COVID, RORA may influence both sleep quality and neuroinflammatory regulation, as it suppresses inflammatory cytokine production in brain tissue.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: RORA
rs11639084 is one of 3 known variants in the RORA gene. To understand the full biological context of this variant, explore the parent gene page.
View RORA gene page →Conditions studied in relation to rs11639084
Research into RORA variants including rs11639084 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include RORA and the rs11639084 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the RORA gene
The following variants in RORA are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs11639084 variant in the RORA gene?
rs11639084 is a single nucleotide polymorphism (SNP) located in the RORA (RAR Related Orphan Receptor A) gene, which is involved in circadian clock. RORA is a nuclear receptor that positively regulates BMAL1 transcription as part of the secondary circadian loop. It also has roles in neuroprotection, immunity, and cholesterol metabolism.
How may the rs11639084 variant relate to Long COVID or ME/CFS?
RORA variants are associated with autism spectrum disorder and sleep problems. In Long COVID, RORA may influence both sleep quality and neuroinflammatory regulation, as it suppresses inflammatory cytokine production in brain tissue.
Can a consumer DNA test detect the rs11639084 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs11639084 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for RORA and its variants. This is not an exhaustive literature review.
- [1]PMID: 24792356
- [2]Nature Neuroscience
- [3]Journal of Immunology