rs3014866
Variant in the S100A9 gene (S100 Calcium Binding Protein A9 (Calprotectin))
rs3014866 is a single nucleotide polymorphism (SNP) in the S100A9 gene, involved in DAMP / myeloid-derived suppressor cells. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs3014866 variant?
rs3014866 is a SNP (single nucleotide polymorphism) in the S100A9 (S100 Calcium Binding Protein A9 (Calprotectin)) gene. It belongs to the Immune Signaling category and is part of the Immune System & Inflammation biological cluster. S100A9 partners with S100A8 to form calprotectin; it also promotes myeloid-derived suppressor cell (MDSC) accumulation and immune suppression.
Biological role and pathway
This variant sits within the S100A9 gene, which is involved in the DAMP / myeloid-derived suppressor cells pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs3014866 and Long COVID / ME-CFS research
S100A9-driven MDSC expansion suppresses T cell immunity; elevated S100A8/S100A9 in Long COVID may contribute to the immunosuppressed T cell phenotype observed in some patients.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: S100A9
rs3014866 is one of 1 known variant in the S100A9 gene. To understand the full biological context of this variant, explore the parent gene page.
View S100A9 gene page →Conditions studied in relation to rs3014866
Research into S100A9 variants including rs3014866 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include S100A9 and the rs3014866 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs3014866 variant in the S100A9 gene?
rs3014866 is a single nucleotide polymorphism (SNP) located in the S100A9 (S100 Calcium Binding Protein A9 (Calprotectin)) gene, which is involved in DAMP / myeloid-derived suppressor cells. S100A9 partners with S100A8 to form calprotectin; it also promotes myeloid-derived suppressor cell (MDSC) accumulation and immune suppression.
How may the rs3014866 variant relate to Long COVID or ME/CFS?
S100A9-driven MDSC expansion suppresses T cell immunity; elevated S100A8/S100A9 in Long COVID may contribute to the immunosuppressed T cell phenotype observed in some patients.
Can a consumer DNA test detect the rs3014866 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs3014866 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for S100A9 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32296168
- [2]Nature Medicine
- [3]Cell