rs9722
Variant in the S100B gene (S100 Calcium Binding Protein B)
rs9722 is a single nucleotide polymorphism (SNP) in the S100B gene, involved in astrocyte/microglial activation biomarker. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs9722 variant?
rs9722 is a SNP (single nucleotide polymorphism) in the S100B (S100 Calcium Binding Protein B) gene. It belongs to the Neurological category and is part of the Neurological & Cognitive Function biological cluster. S100B encodes an astrocyte-derived calcium-binding protein with diverse intracellular and extracellular functions; elevated serum levels indicate brain injury or astrocyte activation.
Biological role and pathway
This variant sits within the S100B gene, which is involved in the astrocyte/microglial activation biomarker pathway. Genes within the Neurological & Cognitive Function cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs9722 and Long COVID / ME-CFS research
Serum S100B is elevated in COVID-19 patients with neurological involvement and may persist in Long COVID; S100B variants may affect astrocyte activation levels and neuroinflammatory signaling.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: S100B
rs9722 is one of 1 known variant in the S100B gene. To understand the full biological context of this variant, explore the parent gene page.
View S100B gene page →Conditions studied in relation to rs9722
Research into S100B variants including rs9722 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include S100B and the rs9722 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs9722 variant in the S100B gene?
rs9722 is a single nucleotide polymorphism (SNP) located in the S100B (S100 Calcium Binding Protein B) gene, which is involved in astrocyte/microglial activation biomarker. S100B encodes an astrocyte-derived calcium-binding protein with diverse intracellular and extracellular functions; elevated serum levels indicate brain injury or astrocyte activation.
How may the rs9722 variant relate to Long COVID or ME/CFS?
Serum S100B is elevated in COVID-19 patients with neurological involvement and may persist in Long COVID; S100B variants may affect astrocyte activation levels and neuroinflammatory signaling.
Can a consumer DNA test detect the rs9722 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs9722 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for S100B and its variants. This is not an exhaustive literature review.
- [1]PMID: 33664986
- [2]Nature Genetics
- [3]Cell