rs6795970
Variant in the SCN10A gene (Sodium Voltage-Gated Channel Alpha Subunit 10 (Nav1.8))
rs6795970 is a single nucleotide polymorphism (SNP) in the SCN10A gene, involved in nociceptive signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs6795970 variant?
rs6795970 is a SNP (single nucleotide polymorphism) in the SCN10A (Sodium Voltage-Gated Channel Alpha Subunit 10 (Nav1.8)) gene. It belongs to the Pain Sensory category and is part of the Pain & Sensory Processing biological cluster. SCN10A encodes Nav1.8, a voltage-gated sodium channel expressed in nociceptors, resistant to inactivation at depolarized voltages.
Biological role and pathway
This variant sits within the SCN10A gene, which is involved in the nociceptive signaling pathway. Genes within the Pain & Sensory Processing cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs6795970 and Long COVID / ME-CFS research
SCN10A variants affecting nociceptor excitability may contribute to dysautonomia and chronic pain sensitization in Long COVID small fiber neuropathy.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: SCN10A
rs6795970 is one of 2 known variants in the SCN10A gene. To understand the full biological context of this variant, explore the parent gene page.
View SCN10A gene page →Conditions studied in relation to rs6795970
Research into SCN10A variants including rs6795970 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SCN10A and the rs6795970 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the SCN10A gene
The following variants in SCN10A are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs6795970 variant in the SCN10A gene?
rs6795970 is a single nucleotide polymorphism (SNP) located in the SCN10A (Sodium Voltage-Gated Channel Alpha Subunit 10 (Nav1.8)) gene, which is involved in nociceptive signaling. SCN10A encodes Nav1.8, a voltage-gated sodium channel expressed in nociceptors, resistant to inactivation at depolarized voltages.
How may the rs6795970 variant relate to Long COVID or ME/CFS?
SCN10A variants affecting nociceptor excitability may contribute to dysautonomia and chronic pain sensitization in Long COVID small fiber neuropathy.
Can a consumer DNA test detect the rs6795970 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs6795970 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for SCN10A and its variants. This is not an exhaustive literature review.
- [1]PMID: 32272069
- [2]Nature Genetics
- [3]Journal of Clinical Investigation