rs9295429
Variant in the SCN1A gene (Sodium Voltage-Gated Channel Alpha Subunit 1)
rs9295429 is a single nucleotide polymorphism (SNP) in the SCN1A gene, involved in neuronal sodium channel / excitability. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs9295429 variant?
rs9295429 is a SNP (single nucleotide polymorphism) in the SCN1A (Sodium Voltage-Gated Channel Alpha Subunit 1) gene. It belongs to the Neurological category and is part of the Neurological & Cognitive Function biological cluster. SCN1A encodes Nav1.1, the primary neuronal sodium channel in inhibitory interneurons; loss-of-function causes Dravet syndrome.
Biological role and pathway
This variant sits within the SCN1A gene, which is involved in the neuronal sodium channel / excitability pathway. Genes within the Neurological & Cognitive Function cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs9295429 and Long COVID / ME-CFS research
SCN1A variants affecting inhibitory interneuron function may contribute to neurological hyperexcitability and sensory sensitization in Long COVID neurological presentations.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: SCN1A
rs9295429 is one of 1 known variant in the SCN1A gene. To understand the full biological context of this variant, explore the parent gene page.
View SCN1A gene page →Conditions studied in relation to rs9295429
Research into SCN1A variants including rs9295429 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SCN1A and the rs9295429 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs9295429 variant in the SCN1A gene?
rs9295429 is a single nucleotide polymorphism (SNP) located in the SCN1A (Sodium Voltage-Gated Channel Alpha Subunit 1) gene, which is involved in neuronal sodium channel / excitability. SCN1A encodes Nav1.1, the primary neuronal sodium channel in inhibitory interneurons; loss-of-function causes Dravet syndrome.
How may the rs9295429 variant relate to Long COVID or ME/CFS?
SCN1A variants affecting inhibitory interneuron function may contribute to neurological hyperexcitability and sensory sensitization in Long COVID neurological presentations.
Can a consumer DNA test detect the rs9295429 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs9295429 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for SCN1A and its variants. This is not an exhaustive literature review.
- [1]PMID: 33664986
- [2]Nature Genetics
- [3]Nature Neuroscience