rs13280585

What is the rs13280585 variant?

rs13280585 is a SNP (single nucleotide polymorphism) in the SCN3B (Sodium Voltage-Gated Channel Beta Subunit 3) gene. It belongs to the Cardiovascular category and is part of the Autonomic Nervous System biological cluster. SCN3B encodes the Nav beta-3 subunit that modulates SCN5A (Nav1.5) channel gating; mutations are linked to Brugada syndrome.

Biological role and pathway

This variant sits within the SCN3B gene, which is involved in the cardiac sodium channel modulation pathway. Genes within the Autonomic Nervous System cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: SCN3B

rs13280585 is one of 1 known variant in the SCN3B gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs13280585

Research into SCN3B variants including rs13280585 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SCN3B and the rs13280585 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions