rs11720524
Variant in the SCN5A gene (Sodium Voltage-Gated Channel Alpha Subunit 5)
rs11720524 is a single nucleotide polymorphism (SNP) in the SCN5A gene, involved in cardiac action potential. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs11720524 variant?
rs11720524 is a SNP (single nucleotide polymorphism) in the SCN5A (Sodium Voltage-Gated Channel Alpha Subunit 5) gene. It belongs to the Autonomic category and is part of the Autonomic Nervous System biological cluster. SCN5A encodes Nav1.5, the predominant cardiac sodium channel that drives the cardiac action potential upstroke.
Biological role and pathway
This variant sits within the SCN5A gene, which is involved in the cardiac action potential pathway. Genes within the Autonomic Nervous System cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs11720524 and Long COVID / ME-CFS research
SCN5A variants may increase cardiac arrhythmia risk; myocarditis and cardiac inflammation from COVID-19 may exacerbate arrhythmic features in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: SCN5A
rs11720524 is one of 2 known variants in the SCN5A gene. To understand the full biological context of this variant, explore the parent gene page.
View SCN5A gene page →Conditions studied in relation to rs11720524
Research into SCN5A variants including rs11720524 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SCN5A and the rs11720524 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the SCN5A gene
The following variants in SCN5A are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs11720524 variant in the SCN5A gene?
rs11720524 is a single nucleotide polymorphism (SNP) located in the SCN5A (Sodium Voltage-Gated Channel Alpha Subunit 5) gene, which is involved in cardiac action potential. SCN5A encodes Nav1.5, the predominant cardiac sodium channel that drives the cardiac action potential upstroke.
How may the rs11720524 variant relate to Long COVID or ME/CFS?
SCN5A variants may increase cardiac arrhythmia risk; myocarditis and cardiac inflammation from COVID-19 may exacerbate arrhythmic features in Long COVID.
Can a consumer DNA test detect the rs11720524 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs11720524 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for SCN5A and its variants. This is not an exhaustive literature review.
- [1]PMID: 33948838
- [2]Nature Genetics
- [3]Journal of Clinical Investigation